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The concomitant administration with the protease inhibitor ritonavir substantially boosts serum concentrations of sildenafil (eleven-fold boost in AUC). If VIAGRA is prescribed to individuals using ritonavir, caution must be applied. Details from topics subjected to high systemic amounts of sildenafil are limited.
The drug data contained herein is subject matter to change and is not intended to protect all feasible uses, Instructions, safety measures, warnings, drug interactions, allergic reactions, or adverse results. The absence of warnings or other information for any specified drug will not point out which the drug or drug combination is Risk-free, helpful, or appropriate for all individuals or all distinct takes advantage of.
Really serious coronary heart signs or symptoms for instance rapidly, irregular, or pounding heartbeats; fluttering with your upper body; shortness of breath; and unexpected dizziness, lightheartedness, or passing out;
For children: This drug isn’t advisable in small children younger than 18 a long time. In one examine, little ones with PAH who took this drug experienced a heightened probability for Dying.
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In the 4 subjects who acquired VIAGRA a hundred mg in the initial aspect of the research, a critical adverse event linked to hypertension outcome was reported in one individual (postural hypotension that started 35 minutes just after dosing with VIAGRA with symptoms lasting for 8 hours), and mild adverse activities perhaps relevant to hypertension outcomes have been documented in two Other individuals (dizziness, headache and tiredness at 1 hour after dosing; and dizziness, lightheadedness and nausea at four hrs following dosing).
i.d.) resulted in the sixty three% decrease of sildenafil AUC plus a fifty five% minimize in sildenafil Cmax . Concomitant administration of powerful CYP3A4 inducers, for example rifampin, is predicted to cause higher decreases in plasma levels of sildenafil.
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In cases of overdose, typical supportive measures should be adopted as required. Renal dialysis is not really expected to speed up clearance as sildenafil is extremely sure to plasma proteins and It isn't eradicated from the urine.
irregular vision, like changes in shade vision (which include getting a blue color tinge) and blurred eyesight
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